Methotraxate Tablet:Anticancer Agent

 What do you mean by methotraxate ?

Methotraxate is an anticancer agent divided into subclass antimetabolites which is used to treat cancer  autoimmune disease like acute lymphotic leukemia,breast cancer ,athritis,rheumatoid athritis,lungs cancer by stopping the de-novo synthesis of DNA by inhibiting the formation of nocleotide that makes up these life sustaining polymer.



What are the Brand Name of  Methotraxate tablet?

Brand names are given by the Pharma companies which may be different according to country,states.Some brand are given below:

Caditrex Tablet

Oncare Tablet

Imutrex Tablet

Oncotrex Tablet

Biotrexate Tablet

Besides these you can also get it by different name in the medical shop.


What are the uses of Methotraxate Tablet?

The uses of Methotraxate tablet are as described.It is used to treat different kinds of cancer like acute lymphoblastic leukaemia, breast cancer in cases of  womenacute lumphotic leukaemia,epidermoid cancer of the head , neck.

It is also used in the treatment of lungs cancer and cancer which starts from bone (autoimmune disease) like rehumetoid athritis.

Diseases related to skin like psoriasis and psoriasis arthritis.Ectopic pregnancy in the women is treated and to terminate early pregnancy if any complication is seen.

Methotraxate is the first antineoplastic agent that produced appreciable remissioon in leukaemia. 


Dosage of Methotraxate

Methotraxate tablet is available in the 2.5 mg, 5 mg. 7.5 mg, 10 mg, 15 mg

Dosesis calculated as 15-30 mg per metre square body surface.

You can take methotraxate before or after meal and 1 tablet in one week. The duration of this medicine is 12-52 weeks.

But in cases of auto immune disorder like psoriasis,arthritis low doses is prescribed. 

Follic acid tablet is given with combination.


What are the mechanism of action of methotraxate?

Methotraxate inhibit dihydrofolate reductase (DHFRase) which converts the dihydrofolic acid to tetrahydro folic acid.The co-enzyme required for one carbon transfer reaction in de-novo purine synthesis and amino acid intercoarse.


Disintgration and Metabolism of methotraxate tablet

Oral absorption is dose dependent and at 80 mg/cm sq. because of site absorption.The monoglutamate tail of methotraxate permits active transport into cells with carrier mediated transport.Once inside the cell, methotraxate undergoes a polyglutamation reaction that adds several anionic carboxylate group to trap at the site of action.Polyglutamation is more efficient in tomour cells than in healthy cells and therefore may promote selective toxocity of this drug.

Cancer cells can become resist to methotraxate over time which attenuated polyglutamation rates.The Polyglutamated drug will be hydrolyzed back to the parents structure before renal elimination.Up to 90% an administered doses of methotraxate is excreted unchanged in the urine within 24 hours.


What are the Side effects of methotraxate tablet?

Some side effect which are seen as follow:

Nausea and vomiting;

Deficiency of white Blood  cell;

Skin rashes;

Weakness;


Warning and precaution

Do not take without doctor's advice ;

Low doses in case of kidney patients;

Avoid this tablet for breast feeding mother;

Some long term uses side effect are heart attack, myocardial infraction, 


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