Dopamine Injection (Intropin) : Uses, Side effects, Dose

In this post we will discuss about dopamine injection side effects, Uses,Doses. It is used in the treatment of cardiogenic shock,  acute kidney failure and hypotension.

What is dopamine?

Human brain secrete Dopamine which is a hormone and neurotransmitters. It is naturally present in the body. It develops the action of the heart. So blood flow properly towards the kidney. Dopamine is catecholamine group of drug that regulate cardiac, vascular and endocrine function. Dopamine injection is D1 receptor and D2 receptor. Along with adrenergic alpha and adrenergic beta 1 receptor agonist. But it does not increase the strength of adrenergic B1 receptor. It is available in the strength of 40 mg/ml, 80 mg/ml, 160 mg/ml.

Dopamine injection Brand Name:

It is also available by generic name dopamine HCL. Some brand available in the market are

Intropin

Resdop

Myocard-DX

Dopar

Actiza

Dopagrin

Flagtropin

Cardidop

Dopan

Dopadic

Dopabas

Dopacin

Comin

Dopa-arc

Beside these this medicine also available by different name in the medical shop. Brands may vary according to countries.

Dopamine injection uses:

Cardiogenic shock:

It treats the cardiogenic shock where cardiac stimulation and peripheral vasoconstriction occurs.

Septic shock:

Dopamjne used in the treatment of hypotension in septic shock. Septic shock is failure of cellular function resulting from decrease in blood supply. 

Renal failure:

It helps in the treatment of reverse Acute kidney failure. This activates the dopamine receptor in the renal and splanchnic circulation. It improves blood supply in this organ area. Also, improvement in the GFR and urinary Na excretion.

Hypotension:

It helps in the treatment of hypotension because of  inadequate cardiac output. Alpha-adrenergic activity of dopamine becomes more prominent at high therapeutic doses. That partially affects the SVR. Due  to diminished SVR, hypotension is treated. Patient whise  blood pressure as well as urine flow haven’t undergone profound deterioration. then prognosis is good. It is in the case of some other circulatory decompensation states.

What is the dosage for  dopamine injection?

Dopamine is available in the concentrated drug solution. So dilute the preparation to 100-fold in isotonic saline. The route of administration is i.v. after diluting.

For renal failure doctor prescribe low doses 1 to 5 micrograms per kg per minutes. It helps to increase kidney blood flow as well as urine output.

Physicians suggest intermediate dose 5 to 15 mcg/kg/minute IV. That improves blood flow in kidney, cardiac output and contractility. Also increase heart rate of patients.

High dose of 20 to 50 mcg per kg per minute give IV to the patients. This injection helps to increase blood pressure and stimulate vasoconstriction. At the intervals of 10 to 30-minute dose can be increased by 1 to 4 mcg/kg/minute. Dose increased until you get desired response only.

Is Dopamine Injection safe for children?

For safety guidelines this injection is not approved for children. Any medical person cannot prescribe for small children.

dopamine-injection-uses
Dopamine injection uses side effect

What is the side effects of dopamine injection?

Tachycardia: It is unusual increase in the heart rate more than 60 times per minute.

  • Bradycardia which is decrease  in the heart rate less than 60 times per minute. 
  • anxiety
  • nausea and vomiting
  • Patients complain  about chest pain
  • palpitations
  • vasoconstriction
  • Patients feel cold
  • Problem in breathing
  • Hand and feet look like blue color
  • Increased blood urea nitrogen.
  • Increased blood urea nitrogen.
  • Heart rhythm become abnormal in patients
  • Unstable blood pressure
  • Sometimes pressure increased in the eye.

Contraindications of Dopamine injection:

Don’t prescribe dopamine to the patients with pheochromocytoma. It causes serious problems in patients with uncorrected tachyarrhythmias or ventricular fibrillation.

Dopamine Interact with:

According to study 198 drugs interact with dopamine. Here are some drugs name

  • Acetylsalicylic Acid (aspirin)
  • Activated Charcoal (charcoal)
  • Adrenalin (epinephrine)
  • Ativan (lorazepam)
  • Atrovent (ipratropium)
  • Benadryl (diphenhydramine)
  • Cardizem (diltiazem)
  • Dextrose (glucose)
  • Heparin Sodium (heparin)
  • Lasix (furosemide)
  • Levophed (norepinephrine)
  • Morphine Sulfate ER (morphine)
  • Paracetamol (acetaminophen)
  • Plavix (clopidogrel)
  • Precedex (dexmedetomidine)
  • Solu-Medrol (methylprednisolone)
  • Valproate Sodium (valproic acid)
  • Versed (midazolam)
  • vitamin K (phytonadione)
  • Zofran (ondansetron)

Apart from these,  there are many drugs which interact with dopamine.  So you must avoid this medicine.

What is dopamine used for?

Dopamine is used for the treatment of low blood pressure,  decreased cardiac output which occure due to trauma or shock. 

What is the price of Dopamine injection?

The price of dopamine injection  vary  according to brand. Price is also different in all countries. We Can’t say fixed price of drugs. For detail information you have to visit medical pharmacy. The average price is $205 for 3000 milliliters of 3.2 mg/ml-D5%.

What is the storage condition for dopamine injection?

Dopamine injection is stored at room temperature i.e. 25° C. Also keep it away  from direct sun light. You have to use diluted solutions of dopamine within 48 hours  at 25 ° C.

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